![]() Blue Cross and Blue Shield of Texas (BCBSTX), is a Division of Health Care. Learn how to use them & get the most out of your health. No dosage adjustment is necessary in patients with mild renal impairment. Your pharmacy benefit includes coverage for many prescription drugs. Kaiser Permanente pharmacies accept select manufacturer coupons for prescription medications.Because of an increase in the exposure of a major metabolite, use of VUMERITY is not recommended in patients with moderate or severe renal impairment No dosage adjustment is necessary in patients with mild renal impairment.USE IN SPECIFIC POPULATIONS Renal Impairment Eosinophilia adverse reactions: A transient increase in mean eosinophil counts was seen during the first 2 months of therapy.Discontinuations due to elevated hepatic transaminases were <1% and were similar in patients treated with dimethyl fumarate or placebo PML has occurred in patients taking dimethyl fumarate in the postmarketing setting in the presence of lymphopenia (2 times the ULN. ![]() Applies to: Dimethyl Fumarate Number of uses: Per prescription per year. A fatal case of PML occurred in a patient who received dimethyl fumarate for 4 years while enrolled in a clinical trial Eligible commercially insured patients may save up to 15 per monthly prescription for additional information contact the program at 33. PML is an opportunistic viral infection of the brain caused by the JC virus (JCV) that typically only occurs in patients who are immunocompromised, and that usually leads to death or severe disability. Anyone with questions or in need of help with locating this medication may call Mylan’s customer service number: (800) 796-9526. Progressive multifocal leukoencephalopathy (PML) has occurred in patients with MS treated with dimethyl fumarate (which has the same active metabolite as VUMERITY).Progressive Multifocal Leukoencephalopathy Patients should be instructed to discontinue VUMERITY and seek immediate medical care should they experience signs and symptoms of anaphylaxis or angioedema Signs and symptoms in patients taking dimethyl fumarate (which has the same active metabolite as VUMERITY) have included difficulty breathing, urticaria, and swelling of the throat and tongue. The ruling by the District Court for the Northern District of West Virginia in favor of Mylan opens the possibility that the company can launch its dimethyl fumarate product, should a request. VUMERITY can cause anaphylaxis and angioedema after the first dose or at any time during treatment. 902 (Tecfidera ): updated advice on the risk of progressive multifocal leukoencephalopathy. Eligible commercially insured patients may save up to 15 per monthly prescription for additional information contact the program at 33.WARNINGS AND PRECAUTIONS Anaphylaxis and Angioedema Reactions may include anaphylaxis and angioedema With known hypersensitivity to diroximel fumarate, dimethyl fumarate, or to any of the excipients of VUMERITY.Important Safety Information CONTRAINDICATIONS VUMERITY is contraindicated in patients VUMERITY ® (diroximel fumarate) is indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.
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